Clinical Management Of Pre Eclampsia - 1631 Words

Scientific Abstract Proteinuria is a measure utilised in the diagnosis of pre-eclampsia. However, there is debate regarding the threshold for significance. The objective of this study was to determine which proteinuria threshold is important for the clinical management of pre-eclampsia in high-risk women, with the specific aim of assessing whether women with 300-499mg/24h of proteinuria could be considered suitable for outpatient management. This was achieved by evaluating incidence of adverse maternal and perinatal outcomes against the differing thresholds of proteinuria in women with pre-eclampsia. The data was collated from a nested case-control of women who partook in a VIP Trial: Vitamins In Pre-eclampsia (2006). 947 women with singleton pregnancies were identified. They were separated into four groups, to compare women with pre-eclampsia and proteinuria (300-499mg/24h or 500mg/24h or over), to women who had no occurrence of proteinuria but had either chronic (CHT) or gestational hypertension (GH). The results of the study clearly indicate that women with proteinuria of 300-499mg/h have more severe hypertension, early deliveries and SGA infants than women managed as outpatients (CHT and GH). However it is apparent those with proteinuria above 500mg/24h are at substantially greater risk of complications than those with a level of 300-499mg/24h. 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